1. Somatic and cardiac dimensions in GH-treated versus untreated patients with TS
No GH (n=19)
Treated with GH (n=67)
Mean (SD)
Range
Mean (SD)
Range
P value
Age (years)
16.5 (4.8)
10 to 25
16.1 (4.3)
10 to 25
.727
Height (cm)
138.6 (11.2)
115.0 to 157.1
145.7 (9.4)
122.0 to 162.7
.004
Weight (kg)
47.4 (16.4)
25.8 to 96.4
50.1 (13.8)
24.2 to 84.9
.309
BMI (kg/m²)
24.2 (5.7)
15.6 to 39.1
23.3 (4.9)
15.4 to 39.4
.855
BSA (m²)
1.3 (0.2)
1.0 to 2.0
1.4 (0.2)
0.9 to 1.9
.070
Septum/BSA (mm/m²)
5.4 (0.9)
4.1 to 6.3
5.2 (0.8)
3.7 to 7.4
.367
PW/BSA (mm/m²)
5.4 (0.9)
4.1 to 6.3
5.1 (0.7)
3.5 to 6.6
.057
LVIDD diastole/BSA (mm/m²)
30.5 (4.4)
22.0 to 39.8
30.5 (4.4)
22.4 to 41.3
.970
LVIDD systole/BSA (mm/m²)
19.2 (2.2)
15.4 to 22.5
19.1 (3.4)
12.0 to 27.9
.948
LVM/BSA (g/m²)
59.1 (16.2)
39.3 to 108.8
63.4 (12.5)
40.6 to 90.7
.224
Fractional shortening
36.1 (8.1)
27.0 to 50.0
37.6 (6.1)
25.0 to 53.7
.422
E/A ratio
1.8 (0.6)
1.0 to 3.2
1.7 (0.5)
1.1 to 3.4
.319 DT
125.1 (36.3)
80.7 to 208.0
140.8 (68.0)
63.6 to 451.0
.409
DT, Mitral deceleration time. E/A ratio is the peak flow velocity in early diastole (E wave) versus that a atrial contraction (A wave). Mean values are compared by analysis of variance, with age as a covariate, followed by Fisher‘s probable least squares difference test. Cardiac measurements are normalized to BSA. Fractional shortening = (LVIDD-IVS)/LVIDD
Abbildung mod. nach Matura, 2007

2. Effect of GH treatment on septum, PW, LVIDD disastole, LVIDD systole, and LVM, controlling for age, years receiving GH therapy, and BSA
Cardiac dimension
Estimate SE
t ratio
P value
Septum
R² = 0.246, P = .0004, n = 67
Intercept
3.604
0.814
4.430
< .0001
Age
0.013
0.039
0.335
.739
Years on GH
0.002
0.043
0.042
.966
BSA
2.363
0.800
2.952
.004
Septum
R² = 0.246, P = .0004, n = 67
Intercept
2.643
0.679
3.892
.0002
Age
0.033
0.092
.927
Years on GH
0.036
0.138
.891
BSA
3.172
0.668
4.748
< .0001
LVID diastole
R² = 0.222, P = .001, n = 67
Intercept
29.230
3.147
9.288
< .0001
Age
0.045
0.151
0.300
.765
Years on GH
0.032
0.166
0.193
.848
BSA
8.422
3.096
2.720
.008
Abbildung mod. nach Matura, 2007

3. Effect of GH treatment on septum, PW, LVIDD disastole, LVIDD systole, and LVM, controlling for age, years receiving GH therapy, and BSA
Cardiac dimension
Estimate SE
t ratio
P value
LVID systole
R² = 0.116, P = .050, n = 67
Intercept
20.344
2.817
7.223
< .0001
Age
0.022
0.135
0.162
.872
Years on GH
0.232
0.149
1.559
.124
BSA
3.140
2.771
1.133
.261 PW
R² = 0.017, P = .778, n = 67
Intercept
80.418
20.737
3.878
.0003
Age
-0.954
0.996
.342
Years on GH
-0.401
1.094
.715
BSA
14.317
20.399
0.702
< .485
Abbildung mod. nach Matura, 2007