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Phase II Trial of Irinotecan, Carboplatin, and Bevacizumab in the Treatment of Patients with Extensive-Stage Small-Cell Lung Cancer  David R. Spigel,

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Presentation on theme: "Phase II Trial of Irinotecan, Carboplatin, and Bevacizumab in the Treatment of Patients with Extensive-Stage Small-Cell Lung Cancer  David R. Spigel,"— Presentation transcript:

1 Phase II Trial of Irinotecan, Carboplatin, and Bevacizumab in the Treatment of Patients with Extensive-Stage Small-Cell Lung Cancer  David R. Spigel, MD, F Anthony Greco, MD, John D. Zubkus, MD, Patrick B. Murphy, MD, Ruben A. Saez, MD, Cindy Farley, CCRP, Denise A. Yardley, MD, Howard A. Burris, MD, John D. Hainsworth, MD  Journal of Thoracic Oncology  Volume 4, Issue 12, Pages (December 2009) DOI: /JTO.0b013e3181bbc540 Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Trial schema illustrating protocol treatment plan.
Journal of Thoracic Oncology 2009 4, DOI: ( /JTO.0b013e3181bbc540) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Time to progression (TTP). Six-month TTP was 76%, a 52% improvement over an historical control of 50%. Median TTP was 9.13 months. Journal of Thoracic Oncology 2009 4, DOI: ( /JTO.0b013e3181bbc540) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Overall survival (OS). Median OS was 12.1 months; 1- and 2-year OS were 51 and 14%, respectively. Journal of Thoracic Oncology 2009 4, DOI: ( /JTO.0b013e3181bbc540) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

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