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N-acetylcysteine leads to greater ovarian protection than enoxaparin sodium in a rat ovarian torsion model  Gulcin Sahin Ersoy, Meryem Eken, Reshef Tal,

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Presentation on theme: "N-acetylcysteine leads to greater ovarian protection than enoxaparin sodium in a rat ovarian torsion model  Gulcin Sahin Ersoy, Meryem Eken, Reshef Tal,"— Presentation transcript:

1 N-acetylcysteine leads to greater ovarian protection than enoxaparin sodium in a rat ovarian torsion model  Gulcin Sahin Ersoy, Meryem Eken, Reshef Tal, Deniz Oztekin, Belgin Devranoglu, Ecmel Isik Kaygusuz, Ozge Cevik  Reproductive BioMedicine Online  Volume 33, Issue 1, Pages (July 2016) DOI: /j.rbmo Copyright © 2016 Reproductive Healthcare Ltd. Terms and Conditions

2 Figure 1 Light microscopic appearance of ovarian morphology (haematoxylin and eosin; ×200). (A) In the control group, primordial follicle (thin arrow), pre-antral follicles (thick arrows), small antral follicle (triangle), large antral follicle (arrowhead), normal vascular structure (star). (B) In the ischaemia/reperfusion group, follicular cell degeneration (thin arrrow), haemorrhage (thick arrow), vascular dilatation (arrowhead), polymorphonuclear leukocytes (star). (C) In the ischaemia/reperfusion + enoxaparin group, haemorrhage (thick arrows), vascular dilatation (arrowhead), follicular cell degeneration (thin arrow). (D) In the ischaemia/reperfusion + NAC group, follicular cell degeneration (thin arrows), minimal vascular dilatation (arrowhead), polymorphonuclear leukocytes (star) and minimal haemorrhage (thick arrow). Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © 2016 Reproductive Healthcare Ltd. Terms and Conditions

3 Figure 2 Histomorphological evaluation of apoptosis by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling (TUNEL) staining in ovaries following I/R injury. Representative light micrographs counterstained with Mayer's haematoxylin are shown. (a) Control group showing no apoptotic cells; (b) ischaemia/reperfusion (I/R) group showing numerous apoptotic cells in the stroma and follicles; (c) I/R + NAC group showing only few apoptotic cells; (d) I/R + enoxaparin group demonstrating more apoptotic cells but less than I/R only group. Arrows indicate TUNEL-positive cells (dark brown nucleus). Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © 2016 Reproductive Healthcare Ltd. Terms and Conditions


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