1. Histopathological examination of kidneys from control or gentamicin-treated rat.
Histopathological examination of kidneys from control or gentamicin-treated rat. Two-micrometer-thick hematoxylin-eosin-stained sections were photographed at 12.5× (left panels) and at 200× (right panels) optical magnification using a Zeiss Axioskop light microscope (Carl Zeiss AG) and a digital camera using the AnalySIS® imaging software (Soft Imaging System). Proximal convoluted tubules (P1/P2 segments) of rats treated for 7 days with 100 mg/kg gentamicin show clear epithelial degeneration and regeneration. Degenerative cells are shrunken and hypereosinophilic, and scattered apoptotic cells are also observed. Regenerative epithelial cells are slightly larger and lightly basophilic, and occasional mitotic figures are present.
Hélène Meistermann et al. Mol Cell Proteomics 2006;5:
© 2006 The American Society for Biochemistry and Molecular Biology