1. Injectable Microsphere Gel Progressively Improves Global Ventricular Function, Regional Contractile Strain, and Mitral Regurgitation After Myocardial Infarction 
Jeremy R. McGarvey, MD, Norihiro Kondo, MD, Walter R.T. Witschey, PhD, Manabu Takebe, MD, Chikashi Aoki, MD, Jason A. Burdick, PhD, Francis G. Spinale, MD, PhD, Joseph H. Gorman, MD, James J. Pilla, PhD, Robert C. Gorman, MD 
The Annals of Thoracic Surgery 
Volume 99, Issue 2, Pages (February 2015)
DOI: /j.athoracsur
Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

2. Fig 1
(A) Three-dimensional radial strain map generated from manually segmented mid-myocardial contours. Two-dimensional short-axis strain maps (inset) are first generated for each myocardial slice from apex to base. Infarct, borderzone, and remote boundaries are then identified. (Inf = infarct region; BZ = borderzone region, Rem = remote region, Apex = left ventricular apex.) (B) to (E) Late gadolinium enhanced and cine images of 4-week untreated control (B) and (C) and 4-week Radiesse-treated (D) and (E) infarcts at end diastole; red arrow denotes infarct area; diffuse Radiesse deposits are visible within the infarct scar as a black void.
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

3. Fig 2
Summary of left ventricular global function indices (left axis) and in vivo posterolateral wall thickness (right axis) at both (A) 1 week and (B) 4 weeks post-infarct in infarct control and Radiesse-treated groups compared with healthy control. (§ = p < 0.05 versus healthy control; * = p < 0.05 vs 4-week infarct control; EF = ejection fraction.)
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

4. Fig 3
Summary of regional radial strain (εmax) at both 1 and 4 weeks post-infarct in infarct control and Radiesse-treated groups compared with healthy control. (§ denotes p < 0.05 vs healthy control; * = p < 0.05 vs 4-week infarct control borderzone myocardium; EDV = end-diastolic volume; EF = ejection fraction; ESV = end-systolic volume; SV = stroke volume.)
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

5. Fig 4
(A) Picro-sirius red collagen staining of healthy, (B) 1-week untreated, (C) 4-weeks untreated, (D) 1-week Radiesse-treated, and (E) 4-weeks Radiesse-treated infarcts. Dense collagen deposits and cellular infiltrates surrounded Radiesse islands in treated infarcts. Collagen deposition was decreased and more homogenous in myocardial infarction controls (original image magnification 40X).
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions