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Ref.: Textbook of Medical Physiology.
13th ed: ,12th. Ed. 11th edition By, Guyton and Hall.
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Physiology Introduction Cell physiology Membrane physiology
Excitable tissues Nerve Muscle
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Fig
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Fig
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NEGATIVE FEEDBACK
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POSITIVE FEEDBACK
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Fig
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Fig 26
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Fig 27
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Tight Junction
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Gap Junction
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Desmosome (Adhering Junction)
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Transport across Plasma Membranes
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Transport across Plasma Membranes
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Transport across Plasma Membranes
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Diffusion through lipid bilayer
CO2 O2 NO Steroid Hormones Monoglycerides
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Diffusion through Biological Membranes
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Simple Diffusion
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Fick’s Law J = P.∆C P = D.A/∆X J = D.A.∆C/∆X
J = Flux (Rate of diffusion) P = Permeability D = Diffusion Coefficient A = Surface area C = Concentration X = Membrane thickness
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Simple Diffusion
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Simple Diffusion
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Facilitated Diffusion
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Facilitated Diffusion
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Facilitated Diffusion
Aminoacids Glucose Galactose Fructose
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Osmosis
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Osmosis
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Osmotic pressure
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Van’t Hoff’s Law π = RTC π : osmotic Pressure R = Gas constant
T = Absolute Temprature C = Concentration
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Tonicity of solution 52
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Hypotonic (cell swells) Isotonic (no change) Hypertonic (cell shrinks)
Figure 25-5; Guyton and Hall 53
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Active Transport Mechanisms
Primary active transport Secondary active transport Vesicular transport
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Types of Pumps Na+/K+ pump H+ pump H+/K+ pump Ca++ pump
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Na+ / K+ Pump
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The importance of pumps for cell functions
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Transport is Controlled by
Activation of receptors - Changing activity of certain enzymes
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Control of Transport
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Receptors & Enzymes
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Receptors & Channels
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Receptors & G proteins
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Control of Exocytosis
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