1. The spectrum expanded: cryptogenic cirrhosis and the natural history of non-alcoholic fatty liver diseasePowell EE, Cooksley WGE, Hanson R, Searle J, Halliday JW, Powell LW. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years [Hepatology 1990; 11:74–80] 
Stephen H Caldwell, Deborah M Crespo 
Journal of Hepatology 
Volume 40, Issue 4, Pages (April 2004)
DOI: /j.jhep

2. Fig. 1
Past series of cryptogenic cirrhosis demonstrating similar gender (mostly female), age (mean of about 60) and only mild ALT abnormality. From Kodali [17], Saunders [18], DiBisceglie [19], Strauss [20], Poonawalla [12] and Caldwell [11].
Journal of Hepatology  , DOI: ( /j.jhep )

3. Fig. 2
Progression of NAFLD to cryptogenic cirrhosis. The explanation for the disappearance of steatosis remains uncertain but it is likely to be multifactorial and to involve changes in blood flow and exposure to fat-promoting hormones as well as possible changes in the intracellular metabolism as a result of long-standing exposure to lipid peroxidation. Theoretically, this could represent a form of lipoatrophy actually occurring within the fat-storing hepatocytes. Other forms of chronic liver disease may also present with a well-established ‘bland’ cirrhosis. Efforts are needed to better define residual markers of past, silent disease in order to improve our understanding of cryptogenic cirrhosis.
Journal of Hepatology  , DOI: ( /j.jhep )