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Bisphenol A and ovarian steroidogenesis

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1 Bisphenol A and ovarian steroidogenesis
Michael S. Bloom, Ph.D., Evelyn Mok-Lin, M.D., Victor Y. Fujimoto, M.D.  Fertility and Sterility  Volume 106, Issue 4, Pages (September 2016) DOI: /j.fertnstert Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Simplified overview of the two-cell ovarian steroidogenesis model, with red lightning bolts indicating bisphenol A (BPA) enzyme targets from the experimental literature. cAMP = cyclic adenosine monophosphate; CREB = cAMP-dependent response element binding protein; CYP450scc = P450 cholesterol side chain cleavage enzyme (CYP11A1); CYP45017α = 17α-hydroxylase-17,20-desmolase (CYP17A1); CYP450arom = cytochrome P450 aromatase (CYP19A1); HSD3β = 3β-hydroxysteroid dehydrogenase; HSD17β = 17β-hydroxysteroid dehydrogenase; IGF = insulin-like growth factor; LRH-1, liver receptor homologue 1; PPAR-γ, peroxisome proliferator–activated receptor γ; SF-1, steroidogenic factor 1; STAR, steroid acute regulatory protein. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions


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