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Reeling in the Catch: Advancing Cleavable Linkers for Proteomics

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Presentation on theme: "Reeling in the Catch: Advancing Cleavable Linkers for Proteomics"— Presentation transcript:

1 Reeling in the Catch: Advancing Cleavable Linkers for Proteomics
Meng M. Rowland, Michael D. Best  Chemistry & Biology  Volume 17, Issue 11, Pages (November 2010) DOI: /j.chembiol Copyright © 2010 Elsevier Ltd Terms and Conditions

2 Figure 1 Cartoon Depicting the Purification of Labeled Proteins using a Diazobenzene-Cleavable Linker Proteins that have been labeled with alkyne- (or azide-) tagged moieties are selectively derivatized using click chemistry and purified through attachment to a solid support. Cleavage of the diazobenzene linker is then used to efficiently release purified proteins to facilitate purification and analysis. Note: for a previous cartoon depicting bioorthogonal labeling using a fishing analogy, see Sletten and Bertozzi, 2009. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2010 Elsevier Ltd Terms and Conditions

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