1. Motor Control: The Curious Case of Cerebrospinal-Fluid-Contacting Neurons 
Michael Jay, Jonathan Robert McDearmid 
Current Biology 
Volume 25, Issue 23, Pages R1138-R1140 (December 2015)
DOI: /j.cub
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2. Figure 1 Connectivity and functional roles of CSF-cNs.
(A) Schematic of known synaptic connections between CSF-cNs, V0-vs and motoneurons (MNs). CSF-cNs (orange) provide GABAergic inputs to V0-vs (dark green) which in turn synapse directly with MNs (light green). The MNs ultimately project into the periphery and innervate the surrounding musculature. (B) Upper panel: schematic of experimental setup. The authors used transgenic fish that express channelrhodopsin in CSF-cNs to selectively activate this cell population (via illumination with blue light). Effects on fictive locomotor output were monitored with ventral root recordings. Middle panel: stimulating CSF-cNs with blue light (blue bars) during periods of rest was sufficient to elicit bouts of fictive locomotion. Lower panel: when blue light was applied just after onset of naturally-occurring fictive locomotion, motor episodes were terminated prematurely.
Current Biology  , R1138-R1140DOI: ( /j.cub )
Copyright © 2015 Elsevier Ltd Terms and Conditions