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External Quality Assessment for Detection of Fetal Trisomy 21, 18, and 13 by Massively Parallel Sequencing in Clinical Laboratories  Rui Zhang, Hongyun.

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Presentation on theme: "External Quality Assessment for Detection of Fetal Trisomy 21, 18, and 13 by Massively Parallel Sequencing in Clinical Laboratories  Rui Zhang, Hongyun."— Presentation transcript:

1 External Quality Assessment for Detection of Fetal Trisomy 21, 18, and 13 by Massively Parallel Sequencing in Clinical Laboratories  Rui Zhang, Hongyun Zhang, Yulong Li, Yanxi Han, Jiehong Xie, Jinming Li  The Journal of Molecular Diagnostics  Volume 18, Issue 2, Pages (March 2016) DOI: /j.jmoldx Copyright © 2016 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

2 Figure 1 A flow diagram of the preparation, validation, and distribution of the samples in noninvasive prenatal testing external quality assessment scheme. The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2016 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

3 Figure 2 The Z values generated for trisomy samples in noninvasive prenatal testing panel by assays on the basis of BGISEQ-100, Bioelectron Seq 4000, and NextSeq CN500. The top, middle, and bottom lines in each box represent the 75th, 50th, and 25th percentiles of Z values, respectively. The error bars represent the maximum and minimum Z values. The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2016 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

4 Figure 3 The numbers of unique sequence reads generated for the trisomy samples in noninvasive prenatal testing panel by assays on the basis of BGISEQ-100, Bioelectron Seq 4000, and NextSeq CN500. The top, middle, and bottom lines in each box represent the 75th, 50th, and 25th percentiles of unique sequence reads, respectively. The error bars represent the maximum and minimum unique sequence reads. Numbers below the plot represent the chromosomal aneuploidies detected. The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2016 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

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