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A Prospective, Molecular Epidemiology Study of EGFR Mutations in Asian Patients with Advanced Non–Small-Cell Lung Cancer of Adenocarcinoma Histology (PIONEER) 

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Presentation on theme: "A Prospective, Molecular Epidemiology Study of EGFR Mutations in Asian Patients with Advanced Non–Small-Cell Lung Cancer of Adenocarcinoma Histology (PIONEER) "— Presentation transcript:

1 A Prospective, Molecular Epidemiology Study of EGFR Mutations in Asian Patients with Advanced Non–Small-Cell Lung Cancer of Adenocarcinoma Histology (PIONEER)  Yuankai Shi, MD, Joseph Siu-Kie Au, MD, Sumitra Thongprasert, MD, Sankar Srinivasan, MBBS, Chun-Ming Tsai, MD, Mai Trong Khoa, MD, Karin Heeroma, Dr Med Sc, Yohji Itoh, PhD, Gerardo Cornelio, MD, Pan-Chyr Yang, MD  Journal of Thoracic Oncology  Volume 9, Issue 2, Pages (February 2014) DOI: /JTO Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Study flow diagram. aTwo patients had major protocol deviations: one patient did not have histologically or cytologically confirmed NSCLC, and one patient had received previous treatment for NSCLC. Three patients were <20 years old and therefore violated the study inclusion criteria. This deviation was considered to be minor and these patients were subsequently included in the PP population. bFour patients had tumor samples that were not tested for EGFR mutations: two biopsy samples were lost after pathological reading, one sample did not have a clot for preparing a tissue block, and the DNA concentration of one block was insufficient for testing. EGFR, epidermal growth factor receptor; NSCLC, non–small-cell lung cancer; PP, per-protocol population. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Combined effect of sex and (A) smoking status and (B) pack-years on frequency of EGFR mutation (PP population). A, p values for logistic regression model. Smoking history definitions: never-smoker (patients who had never smoked cigarettes in their lifetime); ex-smoker (patients who had previously smoked but no longer smoked); occasional smoker (patients who smoked, but not every day); regular smoker (patients who smoked every day). B, p values for logistic regression model. EGFR, epidermal growth factor receptor; PP, per-protocol. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

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