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Anastrozole vs. clomiphene citrate in infertile women with ovulatory dysfunction: a phase II, randomized, dose-finding study  Donald Tredway, M.D., Ph.D.,

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Presentation on theme: "Anastrozole vs. clomiphene citrate in infertile women with ovulatory dysfunction: a phase II, randomized, dose-finding study  Donald Tredway, M.D., Ph.D.,"— Presentation transcript:

1 Anastrozole vs. clomiphene citrate in infertile women with ovulatory dysfunction: a phase II, randomized, dose-finding study  Donald Tredway, M.D., Ph.D., Joan C. Schertz, M.Sc., Daena Bock, M.S., George Hemsey, M.B.A., Michael P. Diamond, M.D.  Fertility and Sterility  Volume 95, Issue 5, Pages e8 (April 2011) DOI: /j.fertnstert Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Mean number of follicles ≥17 mm in diameter over time for all treated patients who ovulated, based on three treatment cycles. AST = anastrozole; CC = clomiphene citrate. Fertility and Sterility  , e8DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

3 Mean (SD) concentration–time profiles of anastrozole in plasma.
Fertility and Sterility  , e8DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

4 Percentage change from baseline to LH surge in median E2 levels for patients who ovulated in cycle 1. AST = anastrozole; CC = clomiphene citrate. Fertility and Sterility  , e8DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

5 Percentage change from baseline to LH surge in median FSH levels for patients who ovulated in cycle 1. AST = anastrozole; CC = clomiphene citrate. Fertility and Sterility  , e8DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

6 Percentage change from baseline to LH surge in median T levels for patients who ovulated in cycle 1. AST = anastrozole; CC = clomiphene citrate. Fertility and Sterility  , e8DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

7 Percentage change from baseline to LH surge in median androstenedione levels for patients who ovulated in cycle 1. AST = anastrozole; CC = clomiphene citrate. Fertility and Sterility  , e8DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions


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