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Volume 21, Issue 4, Pages (November 2003)

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Presentation on theme: "Volume 21, Issue 4, Pages (November 2003)"— Presentation transcript:

1 Volume 21, Issue 4, Pages 982-1004 (November 2003)
Tuberous sclerosis complex and neurofibromatosis type 1: the two most common neurocutaneous diseases  Raymond S Kandt, MD  Neurologic Clinics  Volume 21, Issue 4, Pages (November 2003) DOI: /S (03)

2 Fig. 1 A human figure drawing and printed name by a 5-year-old normally intelligent girl with tuberous sclerosis complex. Neurologic Clinics  , DOI: ( /S (03) )

3 Fig. 2 A hypomelanotic macule of tuberous sclerosis complex.
Neurologic Clinics  , DOI: ( /S (03) )

4 Fig. 3 A small number of flesh-colored tuberous sclerosis complex angiofibromas on the cheek near the nose and a small number in the depression between the lip and chin. Neurologic Clinics  , DOI: ( /S (03) )

5 Fig. 4 More extensive tuberous sclerosis complex angiofibromas. These may bleed with mild trauma. In this boy, the angiofibromas are bright red. Note the gingival fibromas. Neurologic Clinics  , DOI: ( /S (03) )

6 Fig. 5 A flesh-colored ungual fibroma with a central red core.
Neurologic Clinics  , DOI: ( /S (03) )

7 Fig. 6 A traumatic ungual fibroma on the great toe of a patient with back pain and no clinical features of tuberous sclerosis complex. His toe was traumatized with a hammer when he was 6 years old, and it was traumatized again years later with a cast iron skillet that removed the nail. Neurologic Clinics  , DOI: ( /S (03) )

8 Fig. 7 Coronal fluid-attenuated inversion recovery MRI demonstrating a cortical tuber with a migration line extending to the edge of the ventricle. Neurologic Clinics  , DOI: ( /S (03) )

9 Fig. 8 Axial T1-weighted MRI demonstrating subependymal nodules.
Neurologic Clinics  , DOI: ( /S (03) )

10 Fig. 9 Axial T2-weighted MRI demonstrating the same subependymal nodules as in Figure 8. Neurologic Clinics  , DOI: ( /S (03) )

11 Fig. 10 Café au lait spot. Neurologic Clinics  , DOI: ( /S (03) )

12 Fig. 11 Axial T2-weighted MRI of unidentified bright object in the cerebellar white matter. Neurologic Clinics  , DOI: ( /S (03) )


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