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Upregulation of Hypoxia-Inducible Factor-1α mRNA and its Clinical Significance in Non- small Cell Lung Cancer  Tomofumi Yohena, MD, Ichiro Yoshino, MD,

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Presentation on theme: "Upregulation of Hypoxia-Inducible Factor-1α mRNA and its Clinical Significance in Non- small Cell Lung Cancer  Tomofumi Yohena, MD, Ichiro Yoshino, MD,"— Presentation transcript:

1 Upregulation of Hypoxia-Inducible Factor-1α mRNA and its Clinical Significance in Non- small Cell Lung Cancer  Tomofumi Yohena, MD, Ichiro Yoshino, MD, Tomoyoshi Takenaka, MD, Toshifumi Kameyama, MD, Taro Ohba, MD, Yukio Kuniyoshi, MD, Yoshihiko Maehara, MD  Journal of Thoracic Oncology  Volume 4, Issue 3, Pages (March 2009) DOI: /JTO.0b013e d5 Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Immunohistochemical analysis of hypoxia-inducible factor 1α (HIF-1α) protein. Each panel shows the immunohistochemical staining reaction findings using an anti-HIF-1α protein antibody for a representative case. A, A diffuse and strong nuclear expression was recognized in this adenocarcinoma case. B, The HIF-1α expression was either weak or absent in another adenocarcinoma case. Journal of Thoracic Oncology 2009 4, DOI: ( /JTO.0b013e d5) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 The relationship between the expression level of hypoxia-inducible factor 1α (HIF-1α) mRNA and the mRNA expression of the genes located downstream of hypoxia response element (HRE). A, The relationship between the expression levels of HIF-1α mRNA and vascular endothelial growth factor (VEGF) mRNA. A positive correlation was statistically significant (ρ = 0.781, p < ). B, The relationship between the expression level of HIF-1α mRNA and hexokinase II mRNA. A positive correlation was statistically significant (ρ = 0.611, p < ). C, The relationship between the expression levels of HIF-1α mRNA and PRL3 mRNA. The correlation was not significant (ρ = 0.193, p = ). Journal of Thoracic Oncology 2009 4, DOI: ( /JTO.0b013e d5) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 A survival analysis according to the status of the hypoxia-inducible factor 1α (HIF-1α) mRNA expression and of lymph node metastasis. A, A survival curve for all the patients showed no statistically significant difference between the high-expression group and the low-expression group (p = ). B, A survival curve for all the patients showed a significant difference between the lymph node positive and negative cases (p = ). C, A survival curve for the lymph node- negative patients showed a significant difference between the high and low-expression groups (p = ). D, A survival curve for the lymph node- positive patients showed no significant difference between the high and low-expression groups (p = ). Journal of Thoracic Oncology 2009 4, DOI: ( /JTO.0b013e d5) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

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