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Regeneration and fibrous repair
Injury's Repair Regeneration and fibrous repair
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Overview Repair:refers to the restoration of tissue architecure and function after an injury Two types : regeneration fibrous repair scar
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Regeneration physiological regeneration pathological regeneration
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The cell cycle
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Proliferative capacities of tissues
1 labile cells cell groups 2 stable cells 3 permanent cells
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The components of ganulation tissue
Fibrous repair 1 new capillary blood vessels The components of ganulation tissue 2 fibrocyte 3 inflammatory cells
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The functions of ganulation tissue
1 Filling the wound The functions of ganulation tissue 2 Orgnization 3 Anti-infection
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ganulation tissue scar
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The components of scar tissue
1 fibrocyte The components of scar tissue collagen fibrils 2 3 Blood vessels and cells are few
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The functions of scar tissue
beneficial harmful Maintain the integrity of the organ 1 cicatricial contraction 1 2 cicatricial adhesion 2 Maintain the firmness of the organ 3 hypertrophic scar
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Wound healing
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healing by first intention
Eg:the healing of a clean,unifected surgical incision
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During the second week: By the end of the first month:
By day 3: macrophages, granulation tissue During the second week: collagen accumulation and fibroblast proliferation 1 3 5 2 4 By day 5: neovascularization, more fibrils By the end of the first month: mature scar tissue Within 24 hours: inflammatory exudation
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healing by second intention
Eg:the large wounds,abecess formation,ulceration
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Secondary healing differs from primary healing:
1 A larger clot or scab rich in fibrin and fibronectin 2 Inflammation is more intense 3 Much larger amounts of granulation tissue are formed 4 Secondary healing invovles wound contraction
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Fracture healing
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