1. Regeneration and fibrous repair
Injury's Repair
Regeneration and fibrous repair

2. Overview
Repair:refers to the restoration of tissue architecure and function after an injury Two types : regeneration fibrous repair scar

3. Regeneration
physiological regeneration
pathological regeneration

4. The cell cycle

5. Proliferative capacities of tissues1
labile cells
cell
groups 2
stable cells 3
permanent cells

6. The components of ganulation tissue
Fibrous repair 1
new capillary blood vessels
The components of ganulation tissue 2
fibrocyte 3
inflammatory cells

8. The functions of ganulation tissue1
Filling the wound
The functions of ganulation tissue 2
Orgnization 3
Anti-infection

9. ganulation tissue
scar

11. The components of scar tissue1
fibrocyte
The components of scar tissue
collagen fibrils 2 3
Blood vessels and cells are few

12. The functions of scar tissue
beneficial
harmful
Maintain the integrity of the organ 1
cicatricial contraction 1 2
cicatricial adhesion 2
Maintain the firmness of the organ 3
hypertrophic scar

14. Wound healing

15. healing by first intention
Eg:the healing of a clean,unifected
surgical incision

16. During the second week: By the end of the first month:
By day 3:
macrophages,
granulation tissue
During the second week:
collagen accumulation and
fibroblast proliferation 1 3 5 2 4
By day 5:
neovascularization,
more fibrils
By the end of the first month:
mature scar tissue
Within 24 hours:
inflammatory exudation

17. healing by second intention
Eg:the large wounds,abecess
formation,ulceration

18. Secondary healing differs from primary healing:
1 A larger clot or scab rich in fibrin and fibronectin
2 Inflammation is more intense
3 Much larger amounts of granulation tissue are formed
4 Secondary healing invovles wound contraction

19. Fracture healing

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