1. Gut Check: IFNγ Delays Mucosal Recovery during Antibiotic Therapy
Lawton K. Chung, James B. Bliska 
Cell Host & Microbe 
Volume 20, Issue 2, Pages (August 2016)
DOI: /j.chom
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1
Kinetics of Mucosal Inflammation following Salmonella Infection and Subsequent Antibiotic Therapy
At homeostasis there is an absence of mucosal inflammation (Ψ0). Infection with the enteric pathogen Salmonella elicits robust production of pro-inflammatory mediators, including IFNγ from NK cells, leading to mucosal inflammation (Ψmax). Ciprofloxacin treatment rapidly reduces bacterial levels in the gut, but mucosal recovery is much slower (Ψ50), due to the unresolved IFNγ production by NK and T cells. Depletion of NK and T cells accelerates mucosal remission during antibiotic therapy.
Cell Host & Microbe  , DOI: ( /j.chom )
Copyright © 2016 Elsevier Inc. Terms and Conditions