1. The role of the PFC in addiction
Changes in the PFC in addiction

2. Prefrontal cortex (executive processes)
Functions of the PFC
Prefrontal cortex (executive processes)
Self-regulation
Decision making
Cognitive flexibility
Attribution of salience
Volkow, N. D., Koob, G. F., & McLellan, A. T. (2016). Neurobiologic advances from the brain disease model of addiction. New England Journal of Medicine, 374(4),

3. Impaired PFC functioning
The PFC in addiction
Impaired PFC functioning
Poor self-control
Impulsivity
Compulsivity
Volkow, N. D., Koob, G. F., & McLellan, A. T. (2016). Neurobiologic advances from the brain disease model of addiction. New England Journal of Medicine, 374(4),

4. Impaired PFC functioning
The PFC in addiction
Impaired PFC functioning
Poor self-control
Impulsivity
Compulsivity
At the same time impulsive
Patients can be sincere in their desire to stop using a drug
Volkow, N. D., Koob, G. F., & McLellan, A. T. (2016). Neurobiologic advances from the brain disease model of addiction. New England Journal of Medicine, 374(4),

5. Dopaminergic and glutamatergic changes

6. Poor control and high compulisivity
Dopaminergic changes
Poor control and high compulisivity
Altered DA signaling
Koob, G & Kandel, D et al. (2015). Pathophysiology of Addiction. In Tasman, A. . Psychiatry. West Sussex, England: Wiley Blackwell.

7. Glutamate modulates neuroplasticity
Glutamate receptors
Long-term alterations in the PFC
Volkow, N. D., Koob, G. F., & McLellan, A. T. (2016). Neurobiologic advances from the brain disease model of addiction. New England Journal of Medicine, 374(4),