1. CD8 T Cells and IFN-γ Emerge as Critical Players for Psoriasis in a Novel Model of Mouse Psoriasiform Skin Inflammation 
Paola Di Meglio, João H. Duarte 
Journal of Investigative Dermatology 
Volume 133, Issue 4, Pages (April 2013)
DOI: /jid
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2. Figure 1
CD8 T cells mediate Ras-induced psoriasis-like skin inflammation through IFN-γ. Overexpression of activated Ras in suprabasal keratinocytes (KC) resulted in psoriasiform skin inflammation with skin acanthosis, hyperkeratosis, and intraepidermal neutrophil (N) and T-cell infiltration, including IL-17A+IFN-γ+ CD8+ T cytotoxic (Tc1/17) cells. Ras-overexpressing KCs might recruit Tc1/17 cells through the release of CXCL16 interacting with CXCR6 specifically expressed on CD8+ T cells, also possibly bearing very-late antigen (VLA-1) expression, which favors epidermal localization. Proinflammatory cytokines released by Tc1/17 cells, especially IFN-γ, enhance KC activation and proliferation, promoting KC production of neutrophil-attractant CXCL1 and S100 family members (S100A7, S100A8, and S100A9). Moreover, IFN-γ favors Th-17 and IL-17+ γδ-T-cell infiltration into the skin, possibly by programming dendritic cells to produce IL-17-driving cytokines IL-23 and IL-1 and chemoattracting CCL2 and MIP-2.
Journal of Investigative Dermatology  , DOI: ( /jid )
Copyright © 2013 The Society for Investigative Dermatology, Inc Terms and Conditions

3. Journal of Investigative Dermatology 2013 133, 871-874DOI: (10
Journal of Investigative Dermatology  , DOI: ( /jid )
Copyright © 2013 The Society for Investigative Dermatology, Inc Terms and Conditions