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Fludarabine and Pharmacokinetic-Targeted Busulfan before Allografting for Adults with Acute Lymphoid Leukemia  Stella Santarone, Joseph Pidala, Marta.

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Presentation on theme: "Fludarabine and Pharmacokinetic-Targeted Busulfan before Allografting for Adults with Acute Lymphoid Leukemia  Stella Santarone, Joseph Pidala, Marta."— Presentation transcript:

1 Fludarabine and Pharmacokinetic-Targeted Busulfan before Allografting for Adults with Acute Lymphoid Leukemia  Stella Santarone, Joseph Pidala, Marta Di Nicola, Teresa Field, Melissa Alsina, Ernesto Ayala, William Janssen, Mohamed A. Kharfan- Dabaja, Leonel Ochoa, Lia Perez, Janelle Perkins, Jyoti Raychaudhuri, Hugo Fernandez, Claudio Anasetti  Biology of Blood and Marrow Transplantation  Volume 17, Issue 10, Pages (October 2011) DOI: /j.bbmt Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Cumulative incidence of nonrelapse mortality according to age <35 (solid line) vs. age ≥35 (dashed line), P = .73. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Cumulative incidence of relapse, stratified according to remission status at time of transplant (solid line = CR1, dashed line = more advanced disease, including CR2 and -3, and primary induction failure), P = .036 for comparison. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Overall survival, stratified by remission status at time of transplant (dashed line = CR1, solid line = more advanced disease), log-rank P = .06. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 (A) Relapse-free survival from date of transplantation, stratified by remission status (dashed line = CR1, solid line = more advanced disease), log-rank P = .09. (B) Relapse-free survival from date of transplantation, stratified by age (solid line = age <35, dashed line = age ≥35), log-rank P = .79. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions


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