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The Addition of Chemotherapy to Radiation Therapy Improves Survival in Elderly Patients with Stage III Non–Small Cell Lung Cancer  Eric D. Miller, MD,

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Presentation on theme: "The Addition of Chemotherapy to Radiation Therapy Improves Survival in Elderly Patients with Stage III Non–Small Cell Lung Cancer  Eric D. Miller, MD,"— Presentation transcript:

1 The Addition of Chemotherapy to Radiation Therapy Improves Survival in Elderly Patients with Stage III Non–Small Cell Lung Cancer  Eric D. Miller, MD, PhD, James L. Fisher, PhD, Karl E. Haglund, MD, PhD, John C. Grecula, MD, Meng Xu-Welliver, MD, PhD, Erin M. Bertino, MD, Kai He, MD, PhD, Peter G. Shields, MD, David P. Carbone, MD, PhD, Terence M. Williams, MD, PhD, Gregory A. Otterson, MD, Jose G. Bazan, MD, MS  Journal of Thoracic Oncology  Volume 13, Issue 3, Pages (March 2018) DOI: /j.jtho Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Study flow diagram for analytic cohorts. NCDB, National Cancer Database; AJCC, American Joint Committee on Cancer; SBRT, stereotactic body radiation therapy. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Overall survival of patients treated with definitive chemoradiation (CRT) compared with that of patients treated with definitive radiation therapy (RT) alone. Unmatched patient population (A) and propensity score–matched elderly patients (B). All curves represent actual survival as estimated by the Kaplan-Meier method. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

4 Figure 3 Overall survival of patients treated with either single-agent (sCRT) or multiagent chemoradiation (mCRT) compared with that of patients treated with radiation therapy alone (RT). (A) Comparison of sCRT versus definitive RT alone. (B) mCRT versus definitive RT alone. (C) Comparison of mCRT versus sCRT. All analysis was performed using the propensity score–matched patients, and all curves represent actual survival as estimated by the Kaplan-Meier method. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

5 Figure 4 Overall survival of patients treated with definitive concurrent chemoradiation (Con CRT) and definitive sequential chemoradiation (Seq CRT). Unmatched patient population (A) versus propensity score–matched elderly patients (B). All curves represent actual survival as estimated by the Kaplan-Meier method. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

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