1. Fine mapping the MHC region identified rs as a new variant associated with nonobstructive azoospermia in Han Chinese males 
Mingtao Huang, M.D., Meng Zhu, Ph.D., Tingting Jiang, M.D., Yifeng Wang, M.D., Cheng Wang, Ph.D., Guangfu Jin, Ph.D., Xuejiang Guo, Ph.D., Jiahao Sha, Ph.D., Juncheng Dai, Ph.D., Xiaoming Wang, Ph.D., Zhibin Hu, Ph.D. 
Fertility and Sterility 
Volume 111, Issue 1, Pages (January 2019)
DOI: /j.fertnstert
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2. Figure 1
Regional association plots of HLA loci independently associated with nonobstructive azoospermia (NOA) risk. HLA variants, including single-nucleotide polymorphisms (SNPs), indels, classic alleles, and amino acid polymorphisms, were tested for NOA association, using the imputed best-guess genotypes. In each panel, the diamonds represent −log10 (P values) for the variants, and the green line marks Pfdr=0.20. (A) The strongest association was SNP rs7194:A>G (OR 1.37; P=1.43 × 10−6) in HLA-DRA locus. (B) After adjusting for rs7194, the strongest independent signal was SNP rs :A/G>T (OR 1.30; P=2.26 × 10−5) in HLA-B locus. (C) After conditioning for rs7194 and rs , we found no additional independent associations in the MHC region.
Fertility and Sterility  , 61-68DOI: ( /j.fertnstert )
Copyright © 2018 American Society for Reproductive Medicine Terms and Conditions

3. Supplemental Figure 1 Schematic of the study design and work flow.
Fertility and Sterility  , 61-68DOI: ( /j.fertnstert )
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4. Supplemental Figure 2
The LD plot of the statistically significantly associated amino acid polymorphisms within HLA-B, HLA-DRB1, and HLA-DQB1.
Fertility and Sterility  , 61-68DOI: ( /j.fertnstert )
Copyright © 2018 American Society for Reproductive Medicine Terms and Conditions

5. Supplemental Figure 3
The eQTL analysis. Box plot displaying the association of SNPs with gene expression in testis based on GTEx. Expression of genes was normalized by the GTEx Consortium. The box plot displays the first and third quartiles (top and bottom of the boxes), the median (band inside the boxes), and the lowest and highest point within 1.5 times the interquartile range of the lower and higher quartile.
Fertility and Sterility  , 61-68DOI: ( /j.fertnstert )
Copyright © 2018 American Society for Reproductive Medicine Terms and Conditions

6. Supplemental Figure 4
Three-dimensional ribbon model of the HLA-B protein. Residue at the amino acid position 116 is highlighted as red spheres.
Fertility and Sterility  , 61-68DOI: ( /j.fertnstert )
Copyright © 2018 American Society for Reproductive Medicine Terms and Conditions

7. Supplemental Figure 5
Chromosome interaction related to rs in 3DSNP database. In the circular plot, from outer to inner, the circle represents chromatin states, annotated genes, histone modification set (red), transcription factor set (blue), current SNP and associated SNPs, and 3D chromatin interactions, respectively.
Fertility and Sterility  , 61-68DOI: ( /j.fertnstert )
Copyright © 2018 American Society for Reproductive Medicine Terms and Conditions

8. Supplemental Figure 6
Expression profiling of CCHCR1 in human normal tissues based on GTEx database.
Fertility and Sterility  , 61-68DOI: ( /j.fertnstert )
Copyright © 2018 American Society for Reproductive Medicine Terms and Conditions