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New Insights into Genome Structure: Genes of a Feather Stick Together

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1 New Insights into Genome Structure: Genes of a Feather Stick Together
Denes Hnisz, Richard A. Young  Molecular Cell  Volume 67, Issue 5, Pages (September 2017) DOI: /j.molcel Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Mechanisms Structuring the Genome
(A) Topologically Associating Domains (TADs). (B) Top: high-resolution Hi-C in Rowley et al. (2017) reveals small compartmental domains at the boundaries of some TADs in Drosophila. Bottom: molecular underpinnings of TAD boundaries: cohesin associated CTCF-CTCF loops, and gene-gene interactions. (C) Model of genome structuring through phase separation of transcriptional activators and repressors. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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