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5-Hydroxytryptophan (5-HTP)
David Mischoulon, MD, PhD Director, Depression Clinical and Research Program Massachusetts General Hospital Professor of Psychiatry Harvard Medical School
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5-Hydroxytryptophan: Introduction
5-HTP Serotonin Iovieno, N. et al. (2011). Second-tier natural antidepressants: review and critique. Journal of Affective Disorders, 130(3), 343–357.
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Extracted from Griffonia simplicifolia
Studies on 5-HTP are more than 20 years old Less studied since arrival of SSRIs Image: - Iovieno, N. et al. (2011). Second-tier natural antidepressants: review and critique. Journal of Affective Disorders, 130(3), 343–357.
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Eosinophilia-myalgia syndrome
~ 1500 cases At least 38 deaths Banned by the United States FDA Contamination was the result of bad manufacturing standards 5-HTP 5-HTP back on the market Iovieno, N. et al. (2011). Second-tier natural antidepressants: review and critique. Journal of Affective Disorders, 130(3), 343–357.
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Studies on 5-HTP and Depression
Small sample size 6 Showing statistical significance Vs Placebo 27 studies published Doses 1 -2 studies rigorous enough 20 mg / day mg / day 3250 mg / day Dosed times a day Half-life: 4 hours - Iovieno, N. et al. (2011). Second-tier natural antidepressants: review and critique. Journal of Affective Disorders, 130(3), 343–357. - Shaw, K. et al. (2002). Tryptophan and 5-hydroxytryptophan for depression. The Cochrane Database of Systematic Reviews, (1), CD
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Safety Common side effects Nausea Vomiting Diarrhea
Cases of serotonin syndrome when combined with SSRIs or MAOIs Use with caution - Iovieno, N. et al. (2011). Second-tier natural antidepressants: review and critique. Journal of Affective Disorders, 130(3), 343–357. - Shaw, K. et al. (2002). Tryptophan and 5-hydroxytryptophan for depression. The Cochrane Database of Systematic Reviews, (1), CD
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Key Points 5-hydroxytryptophan may be an effective antidepressant working through stimulation of serotonergic mechanisms. Although once banned by the FDA for associated toxic reactions, 5-HTP is currently back on the market and considered safe with current manufacturing standards. Since the 1980s, there has been limited research on 5-HTP for depression and new studies are needed.
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