1. Time Trends of Gastroesophageal Reflux Disease: A Systematic Review
Hashem B. El–Serag 
Clinical Gastroenterology and Hepatology 
Volume 5, Issue 1, Pages (January 2007)
DOI: /j.cgh
Copyright © 2007 AGA Institute Terms and Conditions

2. Figure 1
Prevalence of at least weekly heartburn and/or acid regurgitation, or heartburn, with regard to the publication date of the 17 studies included in the Poisson regression analysis. Studies are categorized by geographic region (continent).
Clinical Gastroenterology and Hepatology 2007 5, 17-26DOI: ( /j.cgh )
Copyright © 2007 AGA Institute Terms and Conditions

3. Figure 2
A funnel plot showing the prevalence of at least weekly heartburn and/or acid regurgitation, or heartburn only, with regard to the sample size of the 45 population-based studies identified by the literature search. The x-axis is in logarithmic scale.
Clinical Gastroenterology and Hepatology 2007 5, 17-26DOI: ( /j.cgh )
Copyright © 2007 AGA Institute Terms and Conditions

4. Figure 3
A funnel plot showing the prevalence of at least weekly heartburn and/or acid regurgitation, or heartburn only, with regard to the sample size of the 17 population-based studies included in the Poisson model. The x-axis is in logarithmic scale.
Clinical Gastroenterology and Hepatology 2007 5, 17-26DOI: ( /j.cgh )
Copyright © 2007 AGA Institute Terms and Conditions

5. Figure 4
Change in the prevalence of reflux symptoms in studies that measured prevalence at more than 1 time point in the same source population. The reflux symptom definitions used were as follows: weekly heartburn and/or acid regurgitation in the U.S. study; “at least mild” heartburn in the 1991–2001 Swedish study; any heartburn and/or acid regurgitation during the past 3 months in the 1988–1995 Swedish study; and monthly heartburn and/or acid regurgitation for the studies in Singapore and China. All bars represent differences between first and second studies except for *, which represents change between 2 periods within the same study.
Clinical Gastroenterology and Hepatology 2007 5, 17-26DOI: ( /j.cgh )
Copyright © 2007 AGA Institute Terms and Conditions

6. Figure 5
Frequency of hospital episodes for GERD per 10,000 hospital episodes. Data obtained from the UK hospital episodes statistics database (
Clinical Gastroenterology and Hepatology 2007 5, 17-26DOI: ( /j.cgh )
Copyright © 2007 AGA Institute Terms and Conditions