1. Figure 1 Cancer stem cell plasticity and stem cell homeostasis in the gut
Figure 1 | Cancer stem cell plasticity and stem cell homeostasis in the gut. The panel on the left illustrates the influence of the microenvironment on colorectal cancer stem cell (CSC) plasticity and tumour survival. The upper right panel highlights the importance of R-spondin 3 (RSPO3) production by myofibroblasts for gastric stem cell activity. Elevated RSPO3 expression in response to Helicobacter pylori infection increases stem cell activity to combat the infection. The lower right panel shows Paneth cells supplying lactate for neighbouring stem cell metabolism in the intestinal crypt, and the cooperative effects of WNT–frizzled (WNT–FZD) and leucine-rich repeat-containing G-protein coupled receptor 5–RSPO (LGR5–RSPO) signalling on intestinal stem cell function.
Barker, N. (2018) Digesting recent stem cell advances in the gut
Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro