1. Nuclear PKCι-ECT2-Rac1 and Ribosome Biogenesis: A Novel Axis in Lung Tumorigenesis 
Martin J. Baker, Mariana Cooke, Marcelo G. Kazanietz 
Cancer Cell 
Volume 31, Issue 2, Pages (February 2017)
DOI: /j.ccell
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2. Figure 1
Different Roles of the Guanine Nucleotide Exchange Factor Ect2
(A) In normal cells, Ect2 is localized to the nucleus during interphase, disperses throughout the cytoplasm upon breakdown of the nuclear lamina, and regulates cytokinesis via RhoA.
(B and C) In lung cancer cells, PKCι-mediated phosphorylation of Ect2 mislocalizes this GEF to the cytoplasm (B) or stimulates nucleolar rDNA transcription (C) via Rac1.
Abbreviations are as follows: ANF, auranofin; NPM, nucleophosmin; Pol 1, RNA polymerase 1; UBF1, Upstream Binding Factor-1. Ect2 localization in cells is depicted in blue.
Cancer Cell  , DOI: ( /j.ccell )
Copyright © 2017 Elsevier Inc. Terms and Conditions