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Liver stem cells and model systems for liver repopulation

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Presentation on theme: "Liver stem cells and model systems for liver repopulation"— Presentation transcript:

1 Liver stem cells and model systems for liver repopulation
David A Shafritz, Mariana D Dabeva  Journal of Hepatology  Volume 36, Issue 4, Pages (April 2002) DOI: /S (02)

2 Fig. 1 Schematic diagram of fetal liver development in the mouse.
Journal of Hepatology  , DOI: ( /S (02) )

3 Fig. 2 The Fischer (F) 344 rat model of liver repopulation by transplanted cells using dipeptidylpeptidase IV (DPPIV) as a detection marker. Isolated cells or cell lines from wild type F344 rats are transplanted to the liver of DPPIV− mutant F344 rats via injection into the splenic pulp or infusion into the portal vein. After engraftment and proliferation, transplanted cells can be detected and their phenotype (hepatocytic or bile duct epithelial) and amount of repopulation determined by enzyme histochemistry for DPPIV. An example of histochemical detection of DPPIV+ hepatocytes and bile duct structures in the liver 1 year after transplantation of fetal liver epithelial cells from a wt F344 rat is shown in the inset. Journal of Hepatology  , DOI: ( /S (02) )

4 Fig. 3 Examples of plasticity of somatic stem cells or stem/progenitor cells isolated from specific organs as determined by their ability to differentiate into different tissue-specific phenotypes when transplanted into different organs. Journal of Hepatology  , DOI: ( /S (02) )

5 Fig. 4 Current status of our understanding of the origin of different endodermal-derived cell populations in the liver and their role in liver development and maintenance of liver mass. Journal of Hepatology  , DOI: ( /S (02) )


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