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Endothelial Cell Injury in Cardiovascular Surgery: The Systemic Inflammatory Response1  Edward M Boyle, MD, Timothy H Pohlman, MD, Marion C Johnson, MD,

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Presentation on theme: "Endothelial Cell Injury in Cardiovascular Surgery: The Systemic Inflammatory Response1  Edward M Boyle, MD, Timothy H Pohlman, MD, Marion C Johnson, MD,"— Presentation transcript:

1 Endothelial Cell Injury in Cardiovascular Surgery: The Systemic Inflammatory Response1 
Edward M Boyle, MD, Timothy H Pohlman, MD, Marion C Johnson, MD, Edward D Verrier, MD  The Annals of Thoracic Surgery  Volume 63, Issue 1, Pages (January 1997) DOI: /S (96)

2 Fig. 1 The disseminated intravascular postpump syndrome. (ICAM = intracellular adhesion molecule; IL = interleukin; TNF = tumor necrosis factor; VCAM = vascular cell adhesion molecule.) The Annals of Thoracic Surgery  , DOI: ( /S (96) )

3 Fig. 2 The classic and alternative pathways of complement activation. The classic pathway requires an antigen-antibody complex to be formed. This occasionally happens when protamine is given to reverse heparin. The alternative pathway is nonspecific, and can be activated by foreign surfaces and the surface of endotoxin. When complement is activated, soluble factors, such as C5a and C3a, are released into the circulation. The Annals of Thoracic Surgery  , DOI: ( /S (96) )

4 Fig. 3 Signal transduction through NF-kB. (ICAM = intracellular adhesion molecule; IL-1 = interleukin-1; LPS = lipopolysaccharide; TNF = tumor necrosis factor.) The Annals of Thoracic Surgery  , DOI: ( /S (96) )


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