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Ulf Lockowandt, MD, Anders Franco-Cereceda, MD, PhD 

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Presentation on theme: "Ulf Lockowandt, MD, Anders Franco-Cereceda, MD, PhD "— Presentation transcript:

1 Is there a role for endothelin-blockade early after coronary artery bypass grafting? 
Ulf Lockowandt, MD, Anders Franco-Cereceda, MD, PhD  The Annals of Thoracic Surgery  Volume 74, Issue 3, Pages (September 2002) DOI: /S (02)

2 Fig 1 (a) Schematic illustration of the experimental protocol in group I (vehicle only for 10 minutes), group II (BQ-123, 260 nmol/min for 10 minutes), and group IV (BQ-123 and BQ-788, 260 and 250 nmol/min, respectively, for 10 minutes). Solid arrow = flow and hemodynamic registration; dashed arrow = blood samples. (b) Schematic illustration of the experimental protocol in group III (BQ-123, 260 nmol/min for 30 minutes) and group V (BQ-123 and BQ-788, 260 and 250 nmol/min, respectively, for 30 minutes). (ACh = acetylcholine; ADO = adenosine.) The Annals of Thoracic Surgery  , DOI: ( /S (02) )

3 Fig 2 (A) Coronary blood flow indirectly measured as vein graft flow after infusions in group I (vehicle only for 10 minutes), group II (BQ-123, 260 nmol/min for 10 minutes), and group IV (BQ-123 and BQ-788, 260 and 250 nmol/min, respectively, for 10 minutes). Values are given as means ± SD. (B) Coronary blood flow indirectly measured as vein graft flow after infusions in group III (BQ-123, 260 nmol/min for 30 minutes) and group V (BQ-123 and BQ-788, 260 and 250 nmol/min, respectively, for 30 minutes). Values are given as means ± SD. The Annals of Thoracic Surgery  , DOI: ( /S (02) )

4 Fig 3 Coronary blood flow indirectly measured as vein graft flow after infusion of acetylcholine (ACh) and adenosine (ADO). Group I (0.9% NaCl only; 1 mL/min for 10 minutes), group II (endothelina blocker BQ-123; 260 nmol/min for 10 minutes), group III (endothelina blocker BQ-123 in combination with endothelinb blocker BQ-788; 260 and 250 nmol/min, respectively, for 10 minutes), group IV (BQ-123; 260 nmol/min for 30 minutes), and group V (BQ-123 in combination with BQ-788; 260 and 250 nmol/min, respectively, for 30 minutes). For significance, see text. Values are given as means ± SD. The Annals of Thoracic Surgery  , DOI: ( /S (02) )

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