1. Expression maps of selected metabolic pathways of Protochlamydia.
Expression maps of selected metabolic pathways of Protochlamydia. A pronounced expression of the ATP/ADP translocase (ntt1) at midcycle and an early-to-mid activity of genes involved in amino acid breakdown to pyruvate is observed, whereas pathways involved in central carbon metabolism and energy generation were generally only upregulated at later stages (with the ATPases indicated by purple boxes being notable exceptions). This suggests that a major metabolic shift occurs during the developmental cycle and provides evidence for a stage-specific metabolism. All genes marked with an asterisk were detected to be significantly differentially expressed. RPKM, reads per kilobase per million; hpi, h postinfection; extracell., extracellular.
Lena König et al. mSystems 2017; doi: /mSystems