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Volume 53, Issue 4, Pages (April 1998)

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1 Volume 53, Issue 4, Pages 945-951 (April 1998)
Na/H exchange and H-K ATPase increase distal tubule acidification in chronic alkalosis  Donald E. Wesson, M.D.  Kidney International  Volume 53, Issue 4, Pages (April 1998) DOI: /j x Copyright © 1998 International Society of Nephrology Terms and Conditions

2 Figure 1 Change in distal tubule net HCO3 reabsorption between the last and first perfusions of perfusion pairs in animals not given bosentan. Abbreviations are: Baf, bafilomycin (10-7M); Sch, Schering (10-5M); and EIPA, ethyl-isopropylamiloride (10-5M). Data are means ±SE. *P < 0.05 versus respective time control. +P < 0.05 versus respective control group. Symbols are: (□) controls; () alkalosis. Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

3 Figure 2 Change in distal tubule net HCO3reabsorption between the last and first perfusions of perfusion pairs in animals given bosentan. Abbreviations are: Baf, bafilomycin (10-7M); Sch, Schering (10-5M); and EIPA, ethyl-isopropylamiloride (10-5M). Data are means ±SE. *P < 0.05 versus respective time control. +P < 0.05 versus respective control group. Symbols are: (□) control; () alkalosis. Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

4 Figure 3 Urine endothelin-1 (ET-1) excretion in a 24 hours collection done on day 28 of the induction protocol (maintenance) and 24 hours after beginning KCl repletion in drinking solution. *P < 0.05 versus respective perfusate without Cl-. *P < 0.05 versus respective control group. +P < 0.05 versus respective maintenance group. Symbols are: (□) control; () alkalosis. Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions


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