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Endothelial Injury, Neutrophil Extracellular Traps, and Complement Activation in Thrombotic Microangiopathy and GVHD  Nicholas J. Gloude, Sonata Jodele,

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Presentation on theme: "Endothelial Injury, Neutrophil Extracellular Traps, and Complement Activation in Thrombotic Microangiopathy and GVHD  Nicholas J. Gloude, Sonata Jodele,"— Presentation transcript:

1 Endothelial Injury, Neutrophil Extracellular Traps, and Complement Activation in Thrombotic Microangiopathy and GVHD  Nicholas J. Gloude, Sonata Jodele, Nathan Luebbering, Kelly E. Lake, Adam Lane, Stella M. Davies  Biology of Blood and Marrow Transplantation  Volume 23, Issue 3, Pages S232-S233 (March 2017) DOI: /j.bbmt Copyright © Terms and Conditions

2 Figure 1 NETs rise during treatment and fall with resolution of TA-TMA. Biology of Blood and Marrow Transplantation  , S232-S233DOI: ( /j.bbmt ) Copyright © Terms and Conditions

3 Figure 2 (A) NETS elevated in children with GVHD prior to TA-TMA therapy. (B) NETs persistently elevated in children with GVHD following resolution of TA-TMA. Biology of Blood and Marrow Transplantation  , S232-S233DOI: ( /j.bbmt ) Copyright © Terms and Conditions

4 Figure 3 1. Chemotherapy, radiation, & infection; 2. Neutrophil activation; 3. NET formation and complement activation; 4. (A) TMA and (B) TMA + GVHD; 5. Resolution of TMA. Biology of Blood and Marrow Transplantation  , S232-S233DOI: ( /j.bbmt ) Copyright © Terms and Conditions


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