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Inducible nitric oxide synthase (iNOS), early growth response protein 2 (Erg2) and podoplanin expression on in vitro-generated inflammatory alveolar macrophages.

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Presentation on theme: "Inducible nitric oxide synthase (iNOS), early growth response protein 2 (Erg2) and podoplanin expression on in vitro-generated inflammatory alveolar macrophages."— Presentation transcript:

1 Inducible nitric oxide synthase (iNOS), early growth response protein 2 (Erg2) and podoplanin expression on in vitro-generated inflammatory alveolar macrophages. Inducible nitric oxide synthase (iNOS), early growth response protein 2 (Erg2) and podoplanin expression on in vitro-generated inflammatory alveolar macrophages. Bronchoalveolar lavage (BAL) alveolar macrophages (AMs) isolated from Pdpnfl/flVAV1cre+ or floxed-only controls (wildtype) were cultured for 24 hours and treated with or without lipopolysaccharide (LPS), in the presence or absence of anti-podoplanin antibody (α-PDPN). (A) Cell surface expression of iNOS, (B) Erg2 and (C) podoplanin assessed by flow cytometry and compared with AMs isolated without culturing (ex vivo). One-way analysis of variance was performed on each parameter with Tukey’s multiple comparisons test (n=5–6).  *P<0.05; **P<0.01; ***P<0.001. N.D., not determined. Sian Lax et al. BMJ Open Resp Res 2017;4:e000257 ©2017 by British Thoracic Society

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