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Patrick J. Smith, PhD, MPH, Jeffrey N. Browndyke, PhD, Zachary A

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1 Longitudinal Changes in Regional Cerebral Perfusion and Cognition After Cardiac Operation 
Patrick J. Smith, PhD, MPH, Jeffrey N. Browndyke, PhD, Zachary A. Monge, MA, Todd B. Harshbarger, PhD, Michael L. James, MD, Jeffrey G. Gaca, MD, John H. Alexander, MD, MHS, Miles M. Berger, MD, PhD, Mark F. Newman, MD, Carmelo A. Milano, MD, Joseph P. Mathew, MD, MHSc  The Annals of Thoracic Surgery  Volume 107, Issue 1, Pages (January 2019) DOI: /j.athoracsur Copyright © 2019 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Changes in perfusion by vascular territory. Significant time by surgical interactions were observed within the (A) middle cerebral artery (MCA) (p = 0.011) and (B) posterior communicating artery (PCA) (p = 0.039) territories, with weaker, nonsignificant changes in the (C) anterior communicating artery (ACA) territories (p = 0.164). (ASL = arterial spin labeling; wk = week.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2019 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Changes in individuals’ subregions within the (left panels) middle cerebral artery (MCA) and (right panels) posterior communicating artery (PCA) territories. As shown, changes were most evident in subregions 9 (p < 0.001), 5 (p = 0.007), 6 (p = 0.011), and 4 (p = 0.090). (ASL = arterial spin labeling; wk = week.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2019 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Changes in middle cerebral artery (MCA) perfusion and psychomotor speed. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2019 The Society of Thoracic Surgeons Terms and Conditions


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