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The Pitfalls of Companion Diagnostics

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1 The Pitfalls of Companion Diagnostics
Scott A. Turner, Jason D. Peterson, Jason R. Pettus, Francine B. de Abreu, Christopher I. Amos, Konstantin H. Dragnev, Gregory J. Tsongalis  The Journal of Molecular Diagnostics  Volume 18, Issue 3, Pages (May 2016) DOI: /j.jmoldx Copyright © 2016 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

2 Figure 1 Hematoxylin and eosin–stained formalin-fixed, paraffin-embedded tissue sections from Patient 1 (tissue section A1) displaying two distinctive morphological patterns. Gross slide with macrodissection annotation (circled region) (A) and corresponding ×10 magnification solid-pattern adenocarcinoma (B). Gross slide with macrodissection annotation (circled regions) (C) and corresponding ×10 magnification enteric-type cribriform pattern adenocarcinoma (D). The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2016 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

3 Figure 2 Epidermal growth factor receptor (EGFR) exon 19 mutation status by capillary electrophoresis fragment analysis. Fragment lengths determined for control samples with no deletion (A), 15-bp deletion (B), and three patient samples: Patient 1 tissue section 1 (C), Patient 1 tissue section 2 (D), and Patient 2 (E). Full exon 19 fragment = 207 bp. The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2016 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

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