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Supplementary Figure S1
FSC SSC FSC-A FSC-H Live/Dead CD3 F4/80 CD11b Ly6G Ly6C b) FSC SSC Live/Dead CD45 CD11b CD3
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Supplementary Figure S2
FSC SSC Live/Dead CD8 CD4 Granzyme-B CD62L CD44 PD-1 Lag3 b) Frequency Exhausted CD8 T-cells p = 0.01 Lag3 (mRNA) Cd3d Cd3g c)
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Supplementary Figure S3
PD-1 PDL-1 CTLA-4 Bulk Tumor b) CD8+ T cells c) CD4+ T cells d) GMDSCs
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Supplementary Figure S4
Panc02 b) Neu-N c) Neu-N
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Supplementary Figure S5
b) Neu-N c) d) Neu-N Panc02
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Supplementary Figure S6
G-MDSCs M-MDSCs a) b) Neu-N c) G-MDSCs d) M-MDSCs Panc02 e) f)
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Supplementary Figure S7
Pathways Downregulated b) Pathways Upregulated c)
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Supplementary Figure S8
Comparison ENT vs. ENT + a-CTLA-4 ENT vs. ENT + a-PD-1 Vehicle vs. ENT Vehicle vs. ENT + a-CTLA-4 Vehicle vs. ENT + a-PD-1
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Supplementary Figure S9
ENT + a-PD-1 + a-CTLA-4 a) Ladder Vehicle ENT ENT + a-PD-1 ENT + a-CTLA-4 Splenic GMDSCs 80 kDa STAT3 50 kDa b-actin 80 kDa pSTAT3 50 kDa b-actin b) c) d) e)
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Supplementary Figure S10
b) Neu-N c) Panc02
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Supplementary Figure S11
b) Neu-N Panc02 c) d) Neu-N Panc02 e) f) Neu-N Panc02 g) h) Panc02 Neu-N
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