1. Metabolic pathway alterations in PCT
Metabolic pathway alterations in PCT. (A) Description of cysteine and methionine metabolism.
Metabolic pathway alterations in PCT. (A) Description of cysteine and methionine metabolism. (B) NAD metabolism and its biological activities. NMN is synthesized from nicotinamide through the catalysis of nicotinamide phosphoribosyltransferase (NAMPT), which is the first step of NAD synthesis by the salvage pathway. NMN is converted into NAD by nicotinamide nucleotide adenylyltransferase (NMNATs) and NAD is subsequently used for NADP generation through mitochondrial NAD kinase (NADKs) catalysis. NADKs are pivotal to balance the NAD pool and NADP pool, which plays a key role in modulating NAD-dependent and NADP-dependent biological reactions. (C) The dysregulation of hexosamine biosynthesis and lysine degradation in prostate cancer. The red and blue fonts indicate significant increases and decreases, respectively, in PCT. ▴: Differential genes or metabolites in discovery and validation phases.
Shancheng Ren et al. Mol Cell Proteomics 2016;15:
© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.