1. By JERLIN G. Research Scholar, Department of Physics.
DRUG DELIVERY SYSTEM By
JERLIN G.
Research Scholar,
Department of Physics.

2. INTRODUCTION
Cellular delivery involving the transfer of various drugs and bio-active molecules (peptides, proteins and DNAs, etc.) through the cell membrane.
Drug delivery systems control the rate at which a drug is released and the location in the body where it is released.  Some systems can control both.

4. Steps involved in drug delivery
1.Surface functionalisation
2.Loading of biomolecules
3.Transport of nanohybrid
4.Interaction of nanohybrids with cell membrane
5.Endocytosis pathways of nanohybrids
6.Rupture of endosomal compartment
7.Release of drug

5. A: inorganic nanoparticle;
B: organically modified inorganic nanoparticle;
C: nanohybrid with DNA loaded;
D: nanohybrid-cell electrostatic attraction;
E: cell recognition of nanohybrid via ‘Y’ (red) and ‘V’ (black) interconnection between the loaded protein and membrane protein;
F: deformation of cell membrane to take up the nanohybrid;
G: nanohybrid endocytosed into cell;
H: nanohybrid-endosome breaking down;
I: DNA released after endosomal breaking

6. Applications
Cancer, AIDS treatment
Antibiotics
Pulmonary infections

7. Advantages Drug targeting of individual tissues
Cells & cellular receptors and hence suitable for gene and vaccine delivery
Controlled delivery drug devices
Less toxic as well as inexpensive

8. Thank you