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Anthony W. H. Chan, FRCPA, Joanna H. M

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1 An Uncommon Insertion Mutation in Exon 19 of EGFR Showed Stable Disease after TKI Treatment 
Anthony W.H. Chan, FRCPA, Joanna H.M. Tong, PhD, Sing-Hung Lo, FRCR, Ka Fai To, FRCPA  Journal of Thoracic Oncology  Volume 8, Issue 12, Pages e107-e108 (December 2013) DOI: /JTO.0b013e3182a471e0 Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 An insertion mutation by duplication of 18 nucleotides at position 2214_2231 (c.2232insTAAAATTCCCGTCGCTAT/ c.2214_2231dup) in exon 19 leads to the insertion of 6 amino acids (p.K745_E746insIPVAIK). Journal of Thoracic Oncology 2013 8, e107-e108DOI: ( /JTO.0b013e3182a471e0) Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Serial chest radiographic findings before and after erlotinib. A, Before treatment: Numerous roundish or oval 2- to 3-mm nodular opacities were diffusely presented in both lungs. B, One month after treatment: Mild shrinkage in size of multiple lung nodules was noted. C, Twelve months after treatment: No significant interval change of multiple lung nodules was observed. D, Eighteen months after treatment: Mild increase in size and extent of multiple lung nodules was evident. Journal of Thoracic Oncology 2013 8, e107-e108DOI: ( /JTO.0b013e3182a471e0) Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

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