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Volume 120, Issue 1, Pages (January 2001)

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Presentation on theme: "Volume 120, Issue 1, Pages (January 2001)"— Presentation transcript:

1 Volume 120, Issue 1, Pages 161-169 (January 2001)
Desensitization to the effects of intravenous octreotide in cirrhotic patients with portal hypertension  Àngels Escorsell, Juan Carlos Bandi, Victòria Andreu, Eduardo Moitinho, Joan Carles Garcí-Pagán, Jaume Bosch, Joan Rodés  Gastroenterology  Volume 120, Issue 1, Pages (January 2001) DOI: /gast Copyright © 2001 American Gastroenterological Association Terms and Conditions

2 Fig. 1 Effects of IV injection of 50 μg octreotide, 500 μg octreotide, or placebo on (A) MAP, (B) HVPG , and (C) AzBF. Data are shown as absolute change from baseline. No significant differences vs. baseline were observed in the placebo group. Changes in MAP and HVPG showed significant differences vs. baseline only at 1 minute in the patients receiving either 50 or 500 μg. The reduction in AzBF was significant from baseline only in patients receiving a 50-μg bolus injection of octreotide at 1 and 5 minutes. Gastroenterology  , DOI: ( /gast ) Copyright © 2001 American Gastroenterological Association Terms and Conditions

3 Fig. 2 Effects of adding a continuous infusion of 50 or 250 μg/h octreotide or placebo to an initial injection of 50 μg octreotide on HVPG (left panel) and AzBF (right panel). Data are shown as absolute change from baseline. HVPG significantly decreased in the 3 groups of patients only at 1 minute. AzBF showed a significant reduction from baseline in the 3 groups at 1 minute of the start of therapy and at 5 and 15 minutes only in patients receiving either 50- or 250-μg/h octreotide infusions. Gastroenterology  , DOI: ( /gast ) Copyright © 2001 American Gastroenterological Association Terms and Conditions

4 Fig. 3 Effects of repeated injections of 50 μg octreotide or placebo after an initial injection of 50 μg octreotide on HVPG (left panel) and MAP (right panel). Data are shown as absolute change from baseline. Octreotide boluses caused a significant decrease in HVPG at 1 minute of its administration. Changes in MAP were only significant at 1 and 5 minutes of the first bolus administration. The following boluses did not cause significant increases in MAP. Gastroenterology  , DOI: ( /gast ) Copyright © 2001 American Gastroenterological Association Terms and Conditions


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