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Carotid atherosclerotic plaques in patients with transient ischemic attacks and stroke have unstable characteristics compared with plaques in asymptomatic.

Published byUlrika Lindberg Modified over 5 years ago

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Presentation on theme: "Carotid atherosclerotic plaques in patients with transient ischemic attacks and stroke have unstable characteristics compared with plaques in asymptomatic."— Presentation transcript:

1 Carotid atherosclerotic plaques in patients with transient ischemic attacks and stroke have unstable characteristics compared with plaques in asymptomatic and amaurosis fugax patients  Bart Verhoeven, MD, Willem E. Hellings, MD, Frans L. Moll, MD, PhD, Jean Paul de Vries, MD, PhD, Dominique P.V. de Kleijn, PhD, Peter de Bruin, MD, PhD, Els Busser, Bsc, Arjen H. Schoneveld, Bsc, Gerard Pasterkamp, MD, PhD  Journal of Vascular Surgery  Volume 42, Issue 6, Pages (December 2005) DOI: /j.jvs Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

2 Fig 1 Plaque processing. The plaque obtained during carotid endarterectomy is divided into 0.5-cm segments. The culprit lesion is designated 0 and is used for histopathologic staining. Other segments are used for protein and DNA/RNA isolation or kept at –80°C. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

3 Fig 2 Clinical symptoms and plaque characteristics. This figure shows different plaque characteristics present at the culprit lesion, for different symptomatic categories. All data are displayed in percentages. AFX, Amaurosis fugax; TIA, transient ischemic attack. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

4 Fig 3 Symptom-free interval and plaque phenotype. Number of patients with specific plaque phenotype and symptom free interval. P values indicate that no differences are observed between distributions of plaque phenotype and increasing symptom-free interval for all patients, transient ischemic attack (TIA), stroke, and amaurosis fugax (AFX), respectively. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

5 Fig 4 Plaque score model. Specific plaque characteristics based on the definition of the vulnerable plaque were given points. The percentage and number of patients with transient ischemic attack (TIA) and stroke related to received points are displayed. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

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