1. Metastasis

2. Cell Types
Basement membrane (basal lamina)- lines cavities of organs, separates them from stroma
Stroma- supporting connective cells

3. Metastasis Cancer cells break through basement membrane
Invade surrounding tissue
(includes blood stream)
spread to other locations

4. Metastasis
Cells from primary tumor can break off and form microscopic tumor masses
remain dormant

5. Angiogenesis! No angiogenesis occurred!
microscopic tumors did not have blood vessels
no nutrients available
growth inhibited!
Primary tumor secretes angiostatin

6. Something to think about…
Patients with good prognosis develop metastases several years after the treatment of their primary tumor
How do we best manage patients?