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Volume 376, Issue 9750, Pages 1401-1408 (October 2010)
Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis Dr Nigel M Williams, PhD, Irina Zaharieva, BSc, Andrew Martin, BSc, Kate Langley, PhD, Kiran Mantripragada, PhD, Ragnheidur Fossdal, PhD, Hreinn Stefansson, PhD, Kari Stefansson, MD, Pall Magnusson, MD, Olafur O Gudmundsson, MD, Omar Gustafsson, PhD, Prof Peter Holmans, PhD, Prof Michael J Owen, MD, Prof Michael O'Donovan, MD, Prof Anita Thapar, MD The Lancet Volume 376, Issue 9750, Pages (October 2010) DOI: /S (10) Copyright © 2010 Elsevier Ltd Terms and Conditions
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Figure 1 CNVs identified at chromosome 16p13.11
Log R ratio and B allele frequency plots of the six copy number variants (CNVs; all duplications) larger than 500 kb identified at the chromosome 16p13.11 region in participants with attention-deficit hyperactivity disorder. The Lancet , DOI: ( /S (10) ) Copyright © 2010 Elsevier Ltd Terms and Conditions
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Figure 2 Positions of CNVs identified at chromosome 16p13.11
The positions of rare copy number variants (CNVs) larger than 500 kb identified at the chromosome 16p13.11 region. Green lines show the six duplications identified in patients with attention-deficit hyperactivity disorder and the red line shows the deletion identified in a single control. The consensus region that is spanned by all CNVs is shown by the arrow. Orange bars show known segmental duplications and therefore the most likely location of the breakpoints for the CNVs identified. The relative locations of genes are based on National Center for Biotechnology Information reference build 36.1 in the University of California Santa Cruz (UCSC) Genome Browser. The Lancet , DOI: ( /S (10) ) Copyright © 2010 Elsevier Ltd Terms and Conditions
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