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Magnesium and the risk of all-cause and cardiac mortality in hemodialysis patients: agent provocateur or innocent bystander?  Cecile Courivaud, Andrew.

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Presentation on theme: "Magnesium and the risk of all-cause and cardiac mortality in hemodialysis patients: agent provocateur or innocent bystander?  Cecile Courivaud, Andrew."— Presentation transcript:

1 Magnesium and the risk of all-cause and cardiac mortality in hemodialysis patients: agent provocateur or innocent bystander?  Cecile Courivaud, Andrew Davenport  Kidney International  Volume 85, Issue 1, Pages (January 2014) DOI: /ki Copyright © 2014 International Society of Nephrology Terms and Conditions

2 Figure 1 Cartoon proposing links between a higher mortality and hypomagnesemia/hypermagnesemia in hemodialysis patients. (a) Hypomagnesemia is commonly associated with increased co-morbidity, and also induces pro-atherosclerotic and pro-thrombotic phenotypes and mineralizing disorders. Moreover, hypomagnesemia is associated with high blood pressure and a higher risk of cardiac arrhythmia. (b) Mild hypermagnesemia may have protective vascular effects, whereas moderate hypermagnesemia reduces osteoid formation and over-supresses PTH leading to vascular calcifications. LDL chol, low-density lipoprotein cholesterol; PTH, parathyroid hormone; TG, triglycerides. Kidney International  , 17-20DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions

3 Figure 2 Intra-patient variability in serum magnesium in 150 stable dialysis outpatients with 4 or more serum magnesium measurements. Data expressed as mean±s.d. Kidney International  , 17-20DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions


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