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IP161. Development of a Hybrid Cryogel-Coated Prosthetic Vascular Graft for Delivery of Targeted Gene Therapies  Cindy Huynh, MD, Ting-Yu Shih, MS, Amruta.

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Presentation on theme: "IP161. Development of a Hybrid Cryogel-Coated Prosthetic Vascular Graft for Delivery of Targeted Gene Therapies  Cindy Huynh, MD, Ting-Yu Shih, MS, Amruta."— Presentation transcript:

1 IP161. Development of a Hybrid Cryogel-Coated Prosthetic Vascular Graft for Delivery of Targeted Gene Therapies  Cindy Huynh, MD, Ting-Yu Shih, MS, Amruta Samant, MS, MSc, Saif G. Pathan, BTech, David W. Nelson, BS, David J. Mooney, PhD, Leena Pradhan-Nabzdyk, PhD, MBA, Frank W. LoGerfo, MD  Journal of Vascular Surgery  Volume 63, Issue 6, Pages 104S-105S (June 2016) DOI: /j.jvs Copyright © Terms and Conditions

2 Fig 1  Characteristics of cryogel-coated prosthetic graft scanning electron microscope (SEM) images demonstrate the microstructure of (A) cryogel, (B) hybrid electrospun polyethylene terephthalate (ePET) graft, and (C) hybrid woven PET graft. After 8 weeks, SEM images of (D) cryogel, (E) hybrid ePET graft, and (F) hybrid woven PET graft reveal minimal degradation of the material. Journal of Vascular Surgery  , 104S-105SDOI: ( /j.jvs ) Copyright © Terms and Conditions

3 Fig 2  Incorporation of cells into cryogel-coated graft. A, Two-dimensional confocal microscopy image of hybrid electrospun polyethylene terephthalate (ePET) graft displays attachment of human aortic endothelial cells (HAoECs) after 24 hours in culture. Three-dimensional reconstructed confocal images depict cell adhesion and integration with (B) hybrid ePET graft and (C) hybrid knitted PET graft. Actin filaments in cells were stained with Alexa Fluor 647 phalloidin (red), cell nuclei stained with DAPI (blue), and alginate stained with fluorescein isothiocyanate (green). Journal of Vascular Surgery  , 104S-105SDOI: ( /j.jvs ) Copyright © Terms and Conditions

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