1. Patient Stories in PAH: Sequential Therapy in a FC II Patient

2. Program Goals

3. Case Study 53-Year-Old Man With IPAH

4. Case Study History

5. Case Study (cont) History

6. Now, 17 Months Later

7. Repeat RHC Findings

8. Sequential Combination Therapy Recommendations for WHO FC II PAH Patients

9. Pharmacologic Agents for PAH 3 Pathways

10. Rationale for Combination Therapy

11. GRIPHON

12. GRIPHON Treatment Effect by Subgroup

13. GRIPHON Titration and Dosing

14. Primary Composite Endpoint in Patients Grouped by Prespecified Selexipag Individual Maintenance Dose vs Placebo

15. Case Summary

16. Abbreviations