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X-Chromosome Inactivation: X Marks the Spot for BRCA1

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Presentation on theme: "X-Chromosome Inactivation: X Marks the Spot for BRCA1"— Presentation transcript:

1 X-Chromosome Inactivation: X Marks the Spot for BRCA1
Caroline Stone, Nuala McCabe, Alan Ashworth  Current Biology  Volume 13, Issue 2, Pages R63-R64 (January 2003) DOI: /S (02)

2 Figure 1 Schematic representation of the effect of loss of BRCA1 on the characteristics of the inactive X chromosome. The inactive X chromosome is visible as the Barr body and associated with XIST RNA. Other features of the inactive X include modification of histone H3 by methylation on lysine 9 (H3mK9) and incorporation of the variant histone mH2A1. These features are lost with loss of BRCA1 function (BRCA1-/-). Current Biology  , R63-R64DOI: ( /S (02) )


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