1. Assessing the Burden of Hyperkalemia

3. Program Goals

4. Program Overview

5. Hyperkalemia Definition, Prevalence, and Clinical Effects

6. Causes of Hyperkalemia

7. Patients at Risk of Hyperkalemia

8. Burden of Hyperkalemia

9. Increasing Incidence of Hyperkalemia

10. Hyperkalemia-Associated ED Visits

11. PARADIGM-HF

12. PARADIGM-HF Hyperkalemia Development During Study

13. Acute Treatment of Hyperkalemia

14. Guidelines Recommendations Regarding RAAS Inhibitor Use Based on Serum K+ Level

15. Chronic Management of Hyperkalemia Before Era of New K+ Binders

16. SPS

17. New K+ Binder Patiromer

18. Emerging K+ Binder ZS-9

19. New and Emerging K+ Binders Efficacy and Safety

20. ZS-9 Treatment Effect in Patients With HF Receiving Maximal, Submaximal, or No RAAS Inhibitor Therapy

21. Long-Term Efficacy and Safety of Patiromer

22. Long-Term Efficacy and Safety of ZS-9

23. Potential Benefits of New and Emerging K+ Binders

24. Management of Hyperkalemia From Acute to Chronic Care

25. Abbreviations

26. Abbreviations (cont)