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The Molecular Basis of Lymphocyte Recruitment to the Skin: Clues for Pathogenesis and Selective Therapies of Inflammatory Disorders  Michael P. Schön,

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Presentation on theme: "The Molecular Basis of Lymphocyte Recruitment to the Skin: Clues for Pathogenesis and Selective Therapies of Inflammatory Disorders  Michael P. Schön,"— Presentation transcript:

1 The Molecular Basis of Lymphocyte Recruitment to the Skin: Clues for Pathogenesis and Selective Therapies of Inflammatory Disorders  Michael P. Schön, Thomas M. Zollner, W-Henning Boehncke  Journal of Investigative Dermatology  Volume 121, Issue 5, Pages (November 2003) DOI: /j x Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 Adhesive interactions and chemokine-driven activation involved in lymphocyte extravasation in the skin. (Bottom) Key steps of interactions with the endothelial lining resulting in extravasation of lymphocytes. (Top) Selected adhesion molecules which mediate these events. Journal of Investigative Dermatology  , DOI: ( /j x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

3 Figure 2 Overview of cellular events involved in dermal and epidermal localization of cutaneous lymphocytes. Similar to Figure 1, the bottom shows cellular interactions of infiltrating lymphocytes with resident extracellular matrix components and cells, whereas the top represents adhesion molecules involved in these interactions. Journal of Investigative Dermatology  , DOI: ( /j x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions


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